Memory B cell
(Redirected from Memory B cells)
Memory B cells are a B cell subtype that are formed within germinal centers following primary infection.
Function[edit | edit source]
Memory B cells can survive for decades and repeatedly generate an antibody response to the antigen that triggered their production. They are responsible for the long-term immunity that results after infection or vaccination.
Formation[edit | edit source]
Memory B cells are formed from activated naive B cells that have encountered their specific antigen during a primary immune response. These cells proliferate and differentiate into plasma cells and memory B cells.
Activation[edit | edit source]
Upon re-exposure to their cognate antigen, memory B cells can differentiate into plasma cells that produce high-affinity antibodies or they can undergo a secondary germinal center reaction.
Types[edit | edit source]
There are two types of memory B cells: the BCR-independent memory B cells and the BCR-dependent memory B cells. The BCR-independent memory B cells are activated by T cells, while the BCR-dependent memory B cells are activated by the antigen itself.
Clinical significance[edit | edit source]
Memory B cells play a crucial role in vaccine-induced immunity. Understanding the mechanisms that regulate their formation and function could lead to the development of more effective vaccines.
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