Metaphit

Metaphit is a chemical compound that was initially developed as a potential analgesic. It is an irreversible inhibitor of the enzyme monoamine oxidase, and has been used in scientific research to create animal models of glutamate neurotoxicity.

History

Metaphit was first synthesized in the 1980s as a potential analgesic. However, it was found to have significant neurotoxic effects, which led to its use in research rather than as a therapeutic drug.

Pharmacology

Metaphit is an irreversible inhibitor of monoamine oxidase, an enzyme that breaks down neurotransmitters such as serotonin, dopamine, and norepinephrine. By inhibiting this enzyme, Metaphit increases the levels of these neurotransmitters in the brain.

In addition to its effects on monoamine oxidase, Metaphit also has effects on the NMDA receptor, a type of glutamate receptor. It acts as a non-competitive antagonist at this receptor, which means it inhibits the receptor's function without binding to the same site as glutamate.

Use in Research

Due to its neurotoxic effects, Metaphit has been used in research to create animal models of glutamate neurotoxicity. This is useful for studying conditions such as Alzheimer's disease and Parkinson's disease, which are thought to involve glutamate-induced damage to neurons.

Safety

Metaphit is a highly toxic compound and should be handled with care. It can cause severe neurological damage if ingested or absorbed through the skin.

See Also

• Phencyclidine
• Ketamine
• Monoamine oxidase inhibitor

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