Methocinnamox

Methocinnamox is a potent opioid antagonist and partial agonist. It is derived from naltrexone and is used in the field of neuropharmacology to study the opioid system. Methocinnamox has a high affinity for the mu opioid receptor, but also binds to the kappa opioid receptor and the delta opioid receptor.

Chemistry

Methocinnamox is a derivative of naltrexone, which is itself a derivative of oxymorphone. The chemical structure of methocinnamox includes a methoxy group, which is responsible for its increased potency compared to naltrexone.

Pharmacology

Methocinnamox acts as an antagonist at the mu opioid receptor, meaning it blocks the effects of opioids at this receptor. However, it also has partial agonist activity, meaning it can activate the receptor to a lesser extent than a full agonist. This dual action makes methocinnamox a unique tool in the study of the opioid system.

Uses

In neuropharmacology, methocinnamox is used to study the opioid system. It can be used to block the effects of opioids, or to mimic their effects to a lesser extent. This can help researchers understand how opioids work and how they can be used in medicine.

Safety

As an opioid antagonist, methocinnamox can precipitate withdrawal symptoms in individuals who are dependent on opioids. Therefore, it should be used with caution in this population.

See also

• Naltrexone
• Opioid receptor
• Neuropharmacology