Methylenedioxyallylamphetamine

'Methylenedioxyallylamphetamine (also known as MDA or Sally) is a psychoactive drug and amphetamine derivative. It is primarily used for its entactogenic effects, which include feelings of increased empathy, euphoria, and sensory enhancement.

Chemistry

Methylenedioxyallylamphetamine is a substituted amphetamine, meaning it contains a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. MDA is substituted at R3 and R4 of the phenyl ring with methylenedioxy functional groups. It is also substituted at Rα with an allyl group. This allyl group is comprised of a methylene bridge (CH2) bound to a vinyl group (C=CH2).

Pharmacology

MDA acts as a serotonin-norepinephrine-dopamine releasing agent (SNDRA). It enters neurons via serotonin transporters and inhibits their reuptake, leading to an increased concentration of these neurotransmitters in the synaptic cleft. This results in increased serotonergic, adrenergic, and dopaminergic neurotransmission.

Effects

The effects of MDA are dose-dependent and can vary greatly among individuals. They can include feelings of love, empathy, and connection to others, increased appreciation of music, enhanced sensory perception, and mild hallucinogenic effects. Negative effects can include anxiety, paranoia, and overstimulation.

Risks

Like other amphetamines, MDA carries risks of neurotoxicity, cardiovascular toxicity, and addiction. It can also cause severe dehydration and hyperthermia in high doses or when used in hot environments.

Legal Status

In many countries, including the United States, MDA is a Schedule I drug under the Controlled Substances Act, meaning it has a high potential for abuse and no accepted medical use.

See Also

• MDMA
• Amphetamine
• Psychedelic drug
• Controlled Substances Act