Metildigoxin
Metildigoxin is a cardiac glycoside, a type of drug that can increase the force of heart contractions, control heart rate, and alleviate symptoms of heart failure. It is a semi-synthetic derivative of digoxin, a naturally occurring cardiac glycoside found in the foxglove plant (Digitalis purpurea).
Pharmacology[edit | edit source]
Metildigoxin works by inhibiting the sodium-potassium ATPase pump in the myocardial (heart muscle) cells. This inhibition leads to an increase in intracellular sodium levels, which then causes an influx of calcium into the cells. The increased calcium levels enhance the force of heart contractions, known as positive inotropy. Additionally, metildigoxin slows the conduction of electrical impulses in the heart, particularly at the atrioventricular node, leading to a slower heart rate.
Clinical Use[edit | edit source]
Metildigoxin is used in the treatment of various heart conditions, including atrial fibrillation, atrial flutter, and heart failure. It is particularly useful in patients with heart failure who also have a rapid irregular heartbeat, as it can control the heart rate and improve symptoms.
Side Effects[edit | edit source]
Like other cardiac glycosides, metildigoxin has a narrow therapeutic index, meaning there is a small difference between a therapeutic dose and a toxic dose. Side effects can include nausea, vomiting, diarrhea, abdominal pain, visual disturbances, and cardiac arrhythmias. In severe cases, metildigoxin toxicity can lead to life-threatening arrhythmias.
See Also[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
This cardiac glycoside related article is a stub. You can help WikiMD by expanding it.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
