Mibefradil
Mibefradil is a calcium channel blocker that was marketed under the brand name Posicor by Roche. It was used in the treatment of hypertension and angina pectoris. However, it was withdrawn from the market in 1998 due to drug interactions.
Pharmacology[edit | edit source]
Mibefradil is a tetralol derivative and acts as a T-type calcium channel blocker. It selectively inhibits T-type calcium channels over L-type calcium channels, which makes it different from other calcium channel blockers. This selectivity allows it to slow down the heart rate without decreasing the force of contraction of the heart.
Clinical Use[edit | edit source]
Mibefradil was approved by the Food and Drug Administration (FDA) in 1997 for the treatment of hypertension and chronic stable angina pectoris. It was marketed as a once-daily medication.
Withdrawal from the Market[edit | edit source]
In 1998, Roche decided to withdraw Mibefradil from the market. This decision was based on reports of severe drug interactions with other medications, including some that could potentially be life-threatening. The drug was found to inhibit the cytochrome P450 enzyme system, which is involved in the metabolism of many other drugs. This inhibition can lead to increased levels of these other drugs in the body, potentially causing toxicity.
See Also[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
