Milan criteria
Milan criteria is a set of criteria used to determine the suitability of a patient with HCC for liver transplant. The criteria were established in Milan, Italy, hence the name.
History[edit]
The Milan criteria were first proposed in 1996 by a team of researchers led by Massimo Colombo. The team conducted a study on patients with HCC who underwent liver transplantation and found that those who met the criteria had a significantly better survival rate.
Criteria[edit]
The Milan criteria include the following:
- One liver tumor that is 5 cm or smaller in diameter.
- Up to three liver tumors, none larger than 3 cm.
- No evidence of cancer spread outside the liver.
Use[edit]
The Milan criteria are widely used around the world to determine the eligibility of patients with HCC for liver transplantation. They are endorsed by the WHO and the AASLD.
Criticism[edit]
Some critics argue that the Milan criteria are too restrictive and exclude many patients who could benefit from a liver transplant. In response to this criticism, several alternative criteria have been proposed, including the UCSF criteria and the Up-to-seven criteria.
See also[edit]
- Liver transplantation
- Hepatocellular carcinoma
- Liver tumor
- Cancer metastasis
- World Health Organization
- American Association for the Study of Liver Diseases
- UCSF criteria
- Up-to-seven criteria
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