Milky spots

Milky spots are small structures found in the peritoneum, specifically in the greater omentum. They are named for their milky-white appearance and play a significant role in the immune response within the peritoneal cavity.

Structure

Milky spots consist of clusters of cells, including macrophages, lymphocytes, mast cells, and dendritic cells. These cells are embedded in a stroma of collagen fibers and extracellular matrix, surrounded by a layer of mesothelial cells.

Function

Milky spots are primarily involved in the immune response within the peritoneal cavity. They act as the first line of defense against peritoneal infections and metastasis. They are capable of trapping foreign particles, bacteria, and tumor cells that enter the peritoneal cavity, and present these to the immune system for destruction.

Clinical significance

Milky spots have been implicated in the spread of ovarian cancer and stomach cancer, as these cancers often metastasize to the peritoneal cavity. They can also become sites of inflammation in response to peritoneal infection or injury.

Research

Research into the role of milky spots in cancer metastasis and the immune response is ongoing. Understanding the function of these structures could lead to new treatments for peritoneal cancers and infections.

See also

• Peritoneum
• Greater omentum
• Immune system