Monocarboxylate transporter 1 inhibitor AZD3965
<languages /><translate> An orally available inhibitor of monocarboxylate transporter 1 (MCT1), with potential antineoplastic activity.
Mechanism of action[edit | edit source]
Upon oral administration, MCT1 inhibitor AZD3965 binds to MCT1 and prevents the transport of lactate into and out of the cell.
Accumulation of lactate[edit | edit source]
This leads to an accumulation of lactate, intracellular acidification, and eventually cancer cell death.
Tumor suppression[edit | edit source]
MCT1, a protein overexpressed on tumor cells, is responsible for the transport of monocarboxylates across the cell membrane and plays a key role in cell metabolism. </translate>
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