Mouse Models of Human Cancer database

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Mouse Models of Human Cancer database (MMHCdb) is an essential resource for researchers in the field of oncology and genetics. The database provides comprehensive information on various mouse models that have been developed to study human cancers. These models are crucial for understanding the mechanisms of cancer development, progression, and for testing new treatments before they are applied in clinical trials.

Overview

The MMHCdb serves as a centralized platform where scientists can find detailed descriptions of mouse models, including their genetic makeup, the type of cancer they are designed to mimic, and the outcomes of various experiments conducted using these models. The database includes information on genetically engineered models, such as transgenic and knockout mice, as well as models that develop cancer through exposure to carcinogens or through the transplantation of human cancer cells.

Importance of Mouse Models in Cancer Research

Mouse models are invaluable in cancer research due to their physiological similarities with humans and their short life cycles, which allow for rapid observation of the effects of genetic modifications and treatments. These models help researchers to:

• Understand the role of specific genes in cancer development
• Study the process of tumor growth and metastasis
• Evaluate the efficacy and safety of new cancer treatments

Features of the MMHCdb

The MMHCdb offers several features to facilitate research, including:

• Detailed model descriptions with information on the genetic alterations, type of cancer, and references to scientific publications
• Search functionality that allows users to find models based on specific criteria, such as cancer type or genetic modification
• A user-friendly interface that enables easy navigation and access to information

Contributing to the MMHCdb

Researchers are encouraged to contribute to the MMHCdb by submitting information on new mouse models they have developed. This collaborative approach ensures that the database remains up-to-date and continues to be a valuable resource for the scientific community.

Conclusion

The Mouse Models of Human Cancer database is a critical tool for researchers studying cancer. By providing detailed information on a wide range of mouse models, the MMHCdb facilitates the understanding of cancer biology and the development of new treatments, ultimately contributing to the advancement of cancer research.