Myeloblast

The myeloblast is a unipotent stem cell, which will differentiate into one of the effectors of the granulocyte series. The stimulation by G-CSF and other cytokines triggers maturation, differentiation, proliferation and cell survival. It exists in the bone marrow and is responsible for producing granulocytes, a type of white blood cell important in the immune response.

Structure

Myeloblasts are relatively large cells, with a diameter of 12-20µm. They have a large nucleus, which can be round or oval, and it contains three to five nucleoli. The cytoplasm is basophilic and contains many free ribosomes. The golgi apparatus is also well developed.

Function

Myeloblasts are responsible for the production of granulocytes, a type of white blood cell. Granulocytes are part of the immune system and are involved in the body's response to infections and inflammation. They are produced in the bone marrow and then released into the bloodstream where they can travel to areas of infection or inflammation.

Clinical significance

Abnormal proliferation of myeloblasts can lead to a type of cancer known as acute myeloblastic leukemia. This is a serious condition that requires immediate medical attention. Symptoms can include fatigue, fever, weight loss, and frequent infections.

See also

• Granulocyte
• White blood cell
• Bone marrow
• Acute myeloblastic leukemia

Myeloblast

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  Myeloblast
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  Two myeloblasts with Auer rods
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  Hematopoiesis (human) diagram
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  Leukopoiese
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  Granulopoiesis