Myelomonocyte

Myelomonocyte is a type of white blood cell that is part of the immune system. It is a precursor cell in the bone marrow that can develop into either a monocyte or a granulocyte, depending on the signals it receives.

Structure and Function

Myelomonocytes are large cells with a round or oval nucleus and a large amount of cytoplasm. They are produced in the bone marrow and released into the bloodstream, where they circulate for a short time before migrating into tissues. There, they can differentiate into either monocytes or granulocytes, depending on the signals they receive from the environment.

Monocytes are a type of white blood cell that can engulf and destroy bacteria, viruses, and other harmful substances. They can also present antigens to T cells, helping to initiate an immune response. Granulocytes, on the other hand, contain granules filled with enzymes and other substances that can kill bacteria and other pathogens. They are particularly important in the immune response to bacterial infections.

Clinical Significance

Abnormalities in the number or function of myelomonocytes can lead to a variety of health problems. For example, a decrease in the number of myelomonocytes can lead to an increased risk of infection, while an increase can indicate an ongoing infection or other medical condition. In addition, mutations in the genes that control the development and function of myelomonocytes can lead to diseases such as chronic granulomatous disease and leukemia.

See Also

• White blood cell
• Monocyte
• Granulocyte
• Bone marrow
• Immune system

References

Myelomonocyte Resources
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