Myelosclerosis

Myelosclerosis is a pathological condition characterized by the hardening of the bone marrow due to fibrosis. This condition is often associated with a group of diseases known as myeloproliferative disorders, which result in an overproduction of blood cells by the bone marrow.

Causes

The exact cause of myelosclerosis is unknown. However, it is often associated with myeloproliferative disorders, such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis. These disorders can cause scarring of the bone marrow, leading to myelosclerosis.

Symptoms

Symptoms of myelosclerosis can vary widely, depending on the severity of the condition and the specific disorder causing it. Common symptoms may include fatigue, weakness, shortness of breath, and easy bruising or bleeding. In more severe cases, patients may experience bone pain, weight loss, and an enlarged spleen (splenomegaly).

Diagnosis

Diagnosis of myelosclerosis typically involves a combination of physical examination, medical history, and laboratory tests. A bone marrow biopsy may be performed to confirm the diagnosis and assess the extent of the fibrosis.

Treatment

Treatment for myelosclerosis focuses on managing the symptoms and complications of the condition. This may involve medications to reduce the production of blood cells, blood transfusions, or in severe cases, a bone marrow transplant.

See also

• Myelofibrosis
• Myeloproliferative neoplasm
• Bone marrow

References

Myelosclerosis Resources
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