Myopalladin

Ideogram human chromosome 10

Myopalladin
Identifiers
Symbol	?

Myopalladin is a protein that in humans is encoded by the MYOP gene. Myopalladin is a structural protein found in muscle cells, specifically in the sarcomeres of striated muscle. It plays a crucial role in maintaining the structural integrity of muscle fibers and contributes to muscle contraction.

Structure

Myopalladin is a large protein consisting of multiple domains, including immunoglobulin-like domains and fibronectin type-III domains. These domains are important for interactions with other proteins in the sarcomere, such as titin and myosin.

Function

Myopalladin functions as a scaffold protein in muscle cells, anchoring various structural and signaling proteins to the sarcomere. It is involved in regulating the assembly and organization of sarcomeric proteins, which are essential for muscle contraction.

Clinical significance

Mutations in the MYOP gene encoding myopalladin have been associated with certain muscle disorders, including myopathies and cardiomyopathies. Disruption of myopalladin function can lead to impaired muscle function and structural abnormalities in muscle fibers.

Interactions

Myopalladin interacts with several other proteins in the sarcomere, such as titin, myosin, and nebulin. These interactions are crucial for the proper functioning of muscle cells and the maintenance of muscle structure.