N,N-dimethylformamide

N,N-dimethylformamide (DMF) is a organic compound with the formula (CH₃)₂NC(O)H. This colorless liquid is miscible with water and the majority of organic liquids. DMF is a common solvent for chemical reactions. DMF is a polar (hydrophilic) aprotic solvent with a high boiling point. It facilitates reactions that follow polar mechanisms, such as SN2 reactions.

Properties

DMF is hydrophilic and can dissolve a wide range of ions and polar and nonpolar compounds. It is a highly effective solvent and is used in the production of acrylic fibers and plastics. It is also used in the development of pesticides, and in the making of synthetic leathers, fibers, films, and surface coatings.

Health Effects

Exposure to DMF can lead to adverse health effects. It can cause abdominal pain, nausea, vomiting, headache, and skin irritation. Chronic exposure can lead to more serious health problems such as liver damage and cancer. Therefore, it is important to handle DMF with care and use appropriate safety measures.

Safety

DMF is not highly flammable but can combust under specific conditions. It is harmful if swallowed, inhaled, or if it comes into contact with the skin. It is recommended to use protective clothing, gloves, and eye/face protection when handling DMF.

See Also

• Dimethyl sulfoxide
• Dimethylacetamide
• Formamide