NED-19

NED-19 is a chemical compound that acts as an inhibitor of the enzyme NAADP (Nicotinic Acid Adenine Dinucleotide Phosphate). It is a potent and selective inhibitor, which has been used in the study of various biological processes and diseases.

Chemistry

NED-19 is a synthetic small molecule, derived from the structure of Naphthalene. It is a non-acidic NAADP antagonist, which means it can inhibit the action of NAADP without affecting the pH of the environment.

Mechanism of Action

NED-19 works by inhibiting the action of NAADP, a potent second messenger in cells that plays a crucial role in the release of calcium ions from intracellular stores. By inhibiting NAADP, NED-19 can effectively regulate calcium signaling within cells.

Applications

Due to its ability to regulate calcium signaling, NED-19 has potential applications in the study and treatment of various diseases. These include neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, where abnormal calcium signaling is often observed. It may also have potential in the treatment of cancer, as calcium signaling plays a key role in cell proliferation and apoptosis.

Research

Research into NED-19 is ongoing, with studies investigating its potential applications in various fields of medicine. These include neurology, oncology, and pharmacology, among others.

See Also

• NAADP
• Calcium signaling
• Neurodegenerative diseases
• Cancer