NLRC3

NLRC3 (NLR family CARD domain containing 3) is a protein that in humans is encoded by the NLRC3 gene. It is a member of the NLR family and has been implicated in the regulation of immune responses.

Function

NLRC3 is a cytosolic protein that is part of the NLR family. It is known to negatively regulate inflammation and autophagy, processes that are crucial for immune responses. NLRC3 is thought to achieve this by inhibiting the activation of mTOR (mechanistic target of rapamycin), a protein that regulates cell growth and survival.

Clinical significance

Alterations in the function or expression of NLRC3 have been associated with several diseases. For example, decreased levels of NLRC3 have been observed in patients with rheumatoid arthritis, suggesting a potential role in the pathogenesis of this disease. Additionally, mutations in the NLRC3 gene have been linked to increased susceptibility to infections and autoimmune diseases.

Research

Research into NLRC3 is ongoing, with studies aiming to further understand its role in immune regulation and its potential as a therapeutic target for various diseases.

See also

• NLR proteins
• Inflammation
• Autophagy
• mTOR

References

NLRC3 Resources
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