NLRP12

NLRP12 is a protein that in humans is encoded by the NLRP12 gene. It is a member of the NOD-like receptor family and plays a crucial role in the regulation of inflammatory pathways and innate immune response.

Function

The protein encoded by the NLRP12 gene is a member of the NOD-like receptor family. These proteins are characterized by a nucleotide-binding domain (NBD) and leucine-rich repeat (LRR) region. This protein has been shown to specifically inhibit the activation of NF-kappaB, and consequently, play a role in the regulation of inflammation and the innate immune response.

Clinical significance

Mutations in the NLRP12 gene have been associated with hereditary periodic fever syndromes, specifically Familial Cold Autoinflammatory Syndrome 2 (FCAS2). This condition is characterized by episodes of fever, skin rash and joint pain.

See also

• NOD-like receptor
• Familial Cold Autoinflammatory Syndrome 2

External links

• NCBI Gene
• UniProt

NLRP12 Resources
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