NLRP6

NLRP6 (NLR family pyrin domain containing 6) is a protein that in humans is encoded by the NLRP6 gene. It is a member of the NLRP family, which is a group of proteins that play a key role in the regulation of innate immune response and inflammation.

Function

NLRP6 is involved in the formation of inflammasomes, which are multiprotein complexes that activate inflammatory responses. It is also involved in the regulation of gut microbiota, the community of microorganisms that live in the digestive tracts of humans. Dysregulation of NLRP6 has been associated with various diseases, including inflammatory bowel disease and colorectal cancer.

Structure

The NLRP6 protein consists of three domains: a pyrin domain, a NACHT domain, and a leucine-rich repeat (LRR) domain. The pyrin domain is involved in protein-protein interactions, the NACHT domain is involved in ATP binding and hydrolysis, and the LRR domain is involved in ligand sensing and protein-protein interactions.

Clinical significance

Alterations in the NLRP6 gene have been associated with a variety of diseases. For example, mutations in this gene have been linked to a higher risk of developing inflammatory bowel disease. Additionally, studies have shown that NLRP6 plays a role in the development of colorectal cancer. It has been suggested that NLRP6 could be a potential therapeutic target for these diseases.

See also

• NLRP
• Inflammasome
• Inflammatory bowel disease
• Colorectal cancer

References

NLRP6 Resources
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