NLRP9
NLRP9 is a protein that in humans is encoded by the NLRP9 gene. It is a member of the NLRP family, which is a group of proteins that play a crucial role in the immune system and inflammation. The NLRP9 protein is involved in the formation of inflammasomes, which are multi-protein complexes that activate inflammatory responses.
Function[edit | edit source]
The NLRP9 protein is part of the larger NLRP family, which is involved in the immune response to pathogens and other harmful substances. These proteins are able to recognize foreign substances and trigger an immune response. Specifically, the NLRP9 protein is involved in the formation of inflammasomes, which are multi-protein complexes that activate inflammatory responses. Inflammasomes are crucial for the body's defense against infections, as they promote the production of pro-inflammatory cytokines.
Clinical significance[edit | edit source]
Alterations in the NLRP9 gene have been associated with various diseases, including inflammatory bowel disease and certain types of cancer. For example, a study found that NLRP9 was overexpressed in colorectal cancer tissues, suggesting that it may play a role in the development of this type of cancer. Further research is needed to fully understand the role of NLRP9 in disease.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
