NME1-NME2

Protein NME1-NME2 PDB 1be4

NME1-NME2

NME1-NME2 is a gene that encodes a protein involved in various cellular processes. This gene is found in humans and is located on chromosome X. The protein encoded by NME1-NME2 is a nucleoside diphosphate kinase that plays a role in the synthesis of nucleoside triphosphates.

Function

The NME1-NME2 gene product functions as a metastasis suppressor and is involved in cell migration and invasion. It also plays a role in DNA repair and replication. Studies have shown that alterations in NME1-NME2 expression levels can impact cancer progression and metastasis.

Clinical Significance

Mutations in the NME1-NME2 gene have been associated with various types of cancer, including breast cancer and colorectal cancer. Understanding the role of NME1-NME2 in cancer development may lead to the development of targeted therapies for these diseases.

Interactions

The protein encoded by NME1-NME2 interacts with several other proteins involved in cell signaling and proliferation. These interactions are important for the regulation of cellular processes and may provide insights into the function of NME1-NME2 in normal and disease states.