NOL3

Ideogram human chromosome 16

NOL3

NOL3, also known as Nucleolar Protein 3, is a protein-coding gene that plays a crucial role in various cellular processes. This gene is located on chromosome 16 in humans and is highly conserved across different species.

Function

NOL3 encodes a protein that is primarily localized in the nucleolus, a subnuclear structure responsible for ribosome biogenesis. The protein encoded by NOL3 is involved in regulating cell survival and apoptosis. It interacts with other proteins to modulate apoptotic pathways and maintain cellular homeostasis.

Clinical Significance

Mutations in the NOL3 gene have been associated with certain diseases, including cancer. Dysregulation of NOL3 expression can impact cell proliferation and survival, contributing to tumorigenesis. Understanding the role of NOL3 in disease pathogenesis may lead to the development of targeted therapies for conditions linked to its dysfunction.

Interactions

NOL3 has been shown to interact with several proteins involved in apoptosis and cell signaling pathways. These interactions are essential for the proper functioning of NOL3 in regulating cell fate decisions and maintaining cellular integrity.