NRCAM

NRCAM (Neuronal Cell Adhesion Molecule) is a protein that in humans is encoded by the NRCAM gene. It is a member of the immunoglobulin superfamily and is primarily expressed in the nervous system. The protein functions as a cell adhesion molecule, mediating cell-cell interactions and regulating cell migration in the nervous system.

Function

NRCAM plays a crucial role in the formation and maintenance of the nervous system. It is involved in the development of neural circuits and the formation of synaptic connections. It mediates cell-cell adhesion through its interactions with other cell adhesion molecules, such as L1 and NCAM. NRCAM also plays a role in axon guidance, contributing to the correct wiring of the nervous system.

Clinical significance

Alterations in the NRCAM gene have been associated with various neurological disorders. For example, mutations in NRCAM have been linked to autism spectrum disorders. Additionally, changes in NRCAM expression have been observed in neurodegenerative diseases such as Alzheimer's disease.

See also

• Cell adhesion molecule
• Immunoglobulin superfamily
• Autism spectrum
• Alzheimer's disease

External links

• NRCAM at the National Center for Biotechnology Information

NRCAM Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski