NRCAM
NRCAM (Neuronal Cell Adhesion Molecule) is a protein that in humans is encoded by the NRCAM gene. It is a member of the immunoglobulin superfamily and is primarily expressed in the nervous system. The protein functions as a cell adhesion molecule, mediating cell-cell interactions and regulating cell migration in the nervous system.
Function[edit | edit source]
NRCAM plays a crucial role in the formation and maintenance of the nervous system. It is involved in the development of neural circuits and the formation of synaptic connections. It mediates cell-cell adhesion through its interactions with other cell adhesion molecules, such as L1 and NCAM. NRCAM also plays a role in axon guidance, contributing to the correct wiring of the nervous system.
Clinical significance[edit | edit source]
Alterations in the NRCAM gene have been associated with various neurological disorders. For example, mutations in NRCAM have been linked to autism spectrum disorders. Additionally, changes in NRCAM expression have been observed in neurodegenerative diseases such as Alzheimer's disease.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- NRCAM at the National Center for Biotechnology Information
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Contributors: Prab R. Tumpati, MD
