NRP-1

NRP-1 or Neuropilin-1 is a protein that in humans is encoded by the NRP1 gene. It is a non-tyrosine-kinase receptor involved in the development of the cardiovascular system and in nervous system and immune functions.

Function

NRP-1 is a receptor for Semaphorin 3A, a secreted class 3 semaphorin, which is involved in axon guidance during neural development. It is also a receptor for Vascular endothelial growth factor (VEGF), which is a signal protein produced by cells that stimulates the formation of blood vessels.

Clinical significance

Alterations in the NRP-1 gene have been associated with various diseases, including cancers and cardiovascular disorders. In cancer, NRP-1 is often overexpressed and contributes to tumor angiogenesis and metastasis. In cardiovascular disorders, NRP-1 plays a role in the formation and remodeling of blood vessels.

See also

• Semaphorin
• Vascular endothelial growth factor
• Angiogenesis
• Metastasis

External links

• NRP1 at the US National Library of Medicine Medical Subject Headings (MeSH)

NRP-1 Resources
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