ALTO-100
(Redirected from NSI-189)
ALTO-100[edit | edit source]
ALTO-100, also known by its developmental code name NSI-189, is an experimental neurogenic compound that has been investigated for its potential use in the treatment of major depressive disorder (MDD) and other neuropsychiatric disorders. It is a small molecule that was originally developed by Neuralstem, Inc., a biotechnology company focused on the development of therapies for central nervous system diseases.
Mechanism of Action[edit | edit source]
ALTO-100 is believed to exert its effects by promoting neurogenesis, the process by which new neurons are formed in the brain. This compound is thought to stimulate the production of neurons in the hippocampus, a region of the brain associated with memory and emotion. The exact mechanism by which ALTO-100 enhances neurogenesis is not fully understood, but it is hypothesized to involve modulation of neurotrophic factors and synaptic plasticity.
Clinical Development[edit | edit source]
ALTO-100 has undergone several phases of clinical trials to evaluate its safety and efficacy in humans. Initial studies focused on its potential to treat major depressive disorder, with some trials indicating that it may improve symptoms of depression and cognitive function. However, results have been mixed, and further research is needed to fully understand its therapeutic potential and safety profile.
Phase I Trials[edit | edit source]
The Phase I clinical trials of ALTO-100 were designed to assess its safety, tolerability, and pharmacokinetics in healthy volunteers. These studies demonstrated that ALTO-100 was generally well-tolerated, with no serious adverse effects reported at the doses tested.
Phase II Trials[edit | edit source]
In Phase II trials, ALTO-100 was tested in patients with major depressive disorder. These studies aimed to evaluate the efficacy of the compound in reducing depressive symptoms and improving cognitive function. Some trials reported positive outcomes, suggesting that ALTO-100 may have antidepressant effects, but the results were not consistent across all studies.
Potential Applications[edit | edit source]
Beyond its potential use in treating major depressive disorder, ALTO-100 is being explored for other applications in neuropsychiatric and neurodegenerative disorders. Its ability to promote neurogenesis and enhance cognitive function makes it a candidate for conditions such as Alzheimer's disease, traumatic brain injury, and stroke.
Challenges and Future Directions[edit | edit source]
The development of ALTO-100 faces several challenges, including the need for more robust clinical data to support its efficacy and safety. Additionally, understanding the precise mechanisms by which it promotes neurogenesis and its long-term effects on brain function are critical areas of ongoing research. Future studies may focus on optimizing dosing regimens, identifying biomarkers for response, and exploring combination therapies to enhance its therapeutic effects.
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