Neoendorphins

Neoendorphins are a type of endorphin, a group of peptides produced by the central nervous system and the pituitary gland. They are known for their ability to induce analgesia and create a feeling of well-being. Neoendorphins were discovered in the 1970s and are classified into two types: α-neoendorphin and β-neoendorphin.

Structure and Function

Neoendorphins are composed of amino acids and are derived from the precursor protein proopiomelanocortin (POMC). The α-neoendorphin is composed of nine amino acids, while the β-neoendorphin is composed of ten.

The primary function of neoendorphins is to interact with opioid receptors in the brain, specifically the kappa opioid receptor. This interaction results in a decrease in the perception of pain, a process known as analgesia. In addition to their analgesic effects, neoendorphins also play a role in regulating mood, respiration, and immune response.

Research and Clinical Significance

Research into neoendorphins has primarily focused on their role in pain management. Studies have shown that increased levels of neoendorphins can result in decreased sensitivity to pain. This has led to the exploration of neoendorphins as potential therapeutic agents in the treatment of chronic pain conditions.

In addition to their role in pain management, neoendorphins have also been implicated in a number of other physiological processes and conditions. These include stress response, addiction, and certain neurological disorders.

See Also

• Endorphin
• Opioid receptor
• Pain management

References

Neoendorphins Resources
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