Neomycin/polymyxin B/bacitracin

Neomycin/Polymyxin B/Bacitracin is a topical antibiotic combination used in the treatment of various types of skin infections. It is a combination of three antibiotics: Neomycin, Polymyxin B, and Bacitracin.

Composition

The combination includes three different antibiotics, each with a unique mechanism of action that targets different types of bacteria.

• Neomycin is an aminoglycoside antibiotic that works by inhibiting protein synthesis in susceptible bacteria, leading to their death.
• Polymyxin B is a polypeptide antibiotic that disrupts the bacterial cell membrane, causing leakage of intracellular contents and cell death.
• Bacitracin is a polypeptide antibiotic that interferes with cell wall synthesis in gram-positive bacteria, leading to their death.

Indications

Neomycin/Polymyxin B/Bacitracin is indicated for the treatment of minor skin infections caused by susceptible strains of bacteria, including Staphylococcus aureus, Streptococcus pyogenes, and certain strains of Pseudomonas aeruginosa and Escherichia coli.

Contraindications

This medication is contraindicated in individuals with a history of hypersensitivity to any of its components. It should not be used in the eyes or applied to large areas of the body.

Side Effects

Common side effects include skin irritation, redness, and rash. Rare but serious side effects include allergic reactions, hearing damage, and kidney damage.

Interactions

Neomycin/Polymyxin B/Bacitracin may interact with other topical medications. It is important to inform healthcare providers of all medications being used prior to starting treatment.

Dosage

The typical dosage is to apply a small amount of the ointment to the affected area 1 to 3 times daily. The duration of treatment depends on the severity and type of infection.

See Also

• Topical antibiotic
• Skin infection
• Bacterial resistance