Nesfatin-1
Peptide involved in appetite regulation and energy homeostasis
Nesfatin-1 is a peptide that plays a significant role in the regulation of appetite and energy homeostasis. It is derived from the precursor protein nucleobindin-2 (NUCB2) and is expressed in various tissues, including the hypothalamus, pancreas, and adipose tissue.
Structure[edit | edit source]
Nesfatin-1 is a peptide consisting of 82 amino acids. It is derived from the N-terminal region of the precursor protein NUCB2. The sequence of nesfatin-1 is highly conserved across different species, indicating its important physiological role.
Function[edit | edit source]
Nesfatin-1 is involved in the regulation of food intake and body weight. It acts as an anorexigenic peptide, meaning it suppresses appetite. Nesfatin-1 exerts its effects by acting on the central nervous system, particularly the hypothalamus, which is a critical region for the regulation of hunger and satiety.
Mechanism of Action[edit | edit source]
Nesfatin-1 influences energy homeostasis by modulating the release of various hormones. It has been shown to stimulate the release of insulin in a glucose-dependent manner, thereby playing a role in glucose metabolism. The peptide interacts with specific receptors in the brain to exert its anorexigenic effects.
Role in Insulin Signaling[edit | edit source]
Nesfatin-1 is involved in the regulation of insulin signaling pathways. It enhances insulin sensitivity and promotes glucose uptake in peripheral tissues. This action is crucial for maintaining normal blood glucose levels and preventing metabolic disorders such as diabetes.
Clinical Significance[edit | edit source]
Due to its role in appetite regulation and energy balance, nesfatin-1 is being studied as a potential therapeutic target for obesity and related metabolic disorders. Understanding the mechanisms by which nesfatin-1 influences energy homeostasis could lead to new treatments for these conditions.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
