Neuropeptide Y receptor
Neuropeptide Y receptor is a class of G protein-coupled receptors that are activated by the neuropeptide Y and peptide YY. The human genes encoding the neuropeptide Y receptors are the NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R.
Function[edit | edit source]
Neuropeptide Y receptors are found in the brain and autonomic nervous system where they regulate a variety of physiological functions including feeding behavior, energy balance, and circadian rhythm. They are also involved in the regulation of mood and anxiety.
Types[edit | edit source]
There are several types of neuropeptide Y receptors, each with its own specific function and distribution in the body.
- NPY1R - This receptor is found in the brain and is involved in the regulation of feeding behavior and energy balance.
- NPY2R - This receptor is found in the brain and peripheral tissues and is involved in the regulation of blood pressure and circadian rhythm.
- NPY4R - This receptor is found in the brain and is involved in the regulation of mood and anxiety.
- NPY5R - This receptor is found in the brain and is involved in the regulation of feeding behavior and energy balance.
- NPY6R - This receptor is found in the peripheral tissues and is involved in the regulation of blood pressure.
Clinical significance[edit | edit source]
Alterations in the function of neuropeptide Y receptors have been implicated in a variety of diseases including obesity, depression, and anxiety disorders. Drugs that target these receptors may have therapeutic potential for these conditions.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD