Neurotensin receptor 1

Neurotensin receptor 1 (NTR1) is a type of protein that in humans is encoded by the NTSR1 gene. It is a high affinity receptor for the neurotensin neuropeptide. Neurotensin receptors are thought to modulate dopamine activity and are implicated in temperature regulation, pain perception, and the regulation of the pituitary gland.

Structure

The NTR1 protein is a member of the G protein-coupled receptor family. It is composed of seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus. The transmembrane domains are connected by three extracellular and three intracellular loops.

Function

Neurotensin receptor 1 is activated by the neurotensin peptide. Upon activation, NTR1 can stimulate phospholipase C and adenylate cyclase, leading to the release of calcium ions from intracellular stores. This can result in a variety of cellular responses, including the modulation of dopamine activity.

Clinical significance

Alterations in the function of neurotensin receptor 1 have been implicated in a variety of disorders, including schizophrenia, Parkinson's disease, and cancer. In particular, overexpression of NTR1 has been observed in certain types of cancer, suggesting a potential role in tumor growth and progression.

See also

• Neurotensin receptor
• Neurotensin
• G protein-coupled receptor
• Dopamine

References

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