Nevus lipomatosus superficialis

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Nevus lipomatosus superficialis (NLS) is a rare, benign skin condition characterized by the presence of mature adipose tissue within the dermis. This condition typically presents as soft, yellowish papules or nodules that can coalesce into larger plaques. NLS is usually asymptomatic and is often discovered incidentally during a routine skin examination.

Clinical Presentation

Nevus lipomatosus superficialis commonly appears in early adulthood, although it can be present at birth or develop later in life. The lesions are most frequently found on the lower back, buttocks, and upper thighs, but they can occur on any part of the body. The lesions are typically soft, non-tender, and may have a wrinkled or cerebriform surface.

Histopathology

Histologically, NLS is characterized by the presence of mature adipocytes within the dermis. These adipocytes are often clustered around blood vessels and sweat glands. The overlying epidermis is usually normal, although it may show some degree of hyperkeratosis or acanthosis.

Differential Diagnosis

The differential diagnosis for NLS includes:

• Lipoma
• Nevus sebaceus
• Connective tissue nevus
• Fibroepithelial polyp
• Neurofibroma

Treatment

Treatment is generally not necessary for NLS, as the condition is benign and asymptomatic. However, for cosmetic reasons or if the lesions become bothersome, surgical excision can be performed. Other treatment options include cryotherapy and laser therapy.

Prognosis

The prognosis for individuals with NLS is excellent, as the condition is benign and does not have any malignant potential. Recurrence after surgical excision is rare.

See Also

• Lipoma
• Adipose tissue
• Dermis
• Skin lesion