Nicarbazin

Nicarbazin

Nicarbazin is a coccidiostat used in the poultry industry. It is a combination of two chemical compounds, 4,4'-dinitrocarbanilide (DNC) and 2-hydroxy-4,6-dimethylpyrimidine (HDP). Nicarbazin is primarily used to control coccidiosis, a parasitic disease that affects the intestinal tract of animals.

History

Nicarbazin was first developed in the 1950s by the pharmaceutical industry as a means to combat coccidiosis in poultry. It was one of the first coccidiostats to be introduced and has since been widely used in the poultry industry worldwide.

Mechanism of Action

The exact mechanism of action of Nicarbazin is not fully understood. However, it is believed that the DNC component interferes with the energy metabolism of the coccidia parasite, while the HDP component inhibits the synthesis of nucleic acids in the parasite.

Usage

Nicarbazin is administered to poultry in their feed. The recommended dosage varies depending on the specific needs of the flock and the severity of the coccidiosis outbreak. It is important to note that Nicarbazin should not be used in laying hens producing eggs for human consumption, as it can lead to egg discoloration and reduced hatchability.

Side Effects

Potential side effects of Nicarbazin include reduced feed intake, weight loss, and decreased egg production. In severe cases, it can cause toxicity and death in poultry. Therefore, it is crucial to monitor the health of the flock closely when administering this drug.

Regulatory Status

In the United States, Nicarbazin is regulated by the Food and Drug Administration (FDA). It is classified as a veterinary drug and its use is subject to specific regulations and restrictions.

See Also

• Coccidiosis
• Poultry farming
• Veterinary medicine

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