Nicogrelate
Nicogrelate is a pharmaceutical compound that functions primarily as an antiplatelet agent. It is used in the prevention of thrombotic events, particularly in patients with cardiovascular diseases. This article provides a comprehensive overview of Nicogrelate, including its mechanism of action, clinical applications, pharmacokinetics, and potential side effects.
Mechanism of Action[edit | edit source]
Nicogrelate works by inhibiting platelet aggregation, which is a crucial step in the formation of blood clots. It achieves this by blocking the adenosine diphosphate (ADP) receptors on the surface of platelets. This inhibition prevents the activation of the glycoprotein IIb/IIIa complex, which is essential for platelet aggregation.
Clinical Applications[edit | edit source]
Nicogrelate is primarily used in the management of patients with a high risk of thrombotic events, such as those with coronary artery disease, peripheral artery disease, or a history of myocardial infarction. It is often prescribed as part of a dual antiplatelet therapy regimen, in combination with aspirin, to enhance its efficacy.
Pharmacokinetics[edit | edit source]
The pharmacokinetic profile of Nicogrelate includes rapid absorption following oral administration, with peak plasma concentrations typically reached within 1 to 2 hours. It is metabolized in the liver and excreted primarily via the kidneys. The half-life of Nicogrelate is approximately 6 to 8 hours, necessitating twice-daily dosing in most therapeutic regimens.
Side Effects[edit | edit source]
Common side effects of Nicogrelate include gastrointestinal disturbances such as nausea and dyspepsia, as well as an increased risk of bleeding. Patients should be monitored for signs of bleeding, and the drug should be used with caution in individuals with a history of bleeding disorders.
Contraindications[edit | edit source]
Nicogrelate is contraindicated in patients with active pathological bleeding, such as peptic ulcer disease or intracranial hemorrhage. It should also be avoided in patients with known hypersensitivity to the drug or any of its components.
Also see[edit | edit source]
| Nicogrelate_structure.png | |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
