Noninvasive follicular thyroid neoplasm with papillary-like nuclear features
A type of thyroid neoplasm
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a type of thyroid neoplasm that exhibits certain histological characteristics similar to papillary thyroid carcinoma (PTC) but is considered to have a very low risk of malignancy. This entity was introduced to reduce overtreatment of indolent thyroid tumors.
Histopathology[edit | edit source]
NIFTP is characterized by a follicular growth pattern and nuclear features similar to those seen in papillary thyroid carcinoma. The tumor is encapsulated or well-circumscribed, and there is no evidence of invasion into the surrounding thyroid tissue or blood vessels.
The nuclear features include:
- Nuclear enlargement
- Overlapping and crowding
- Irregular nuclear contours
- Optical clearing of the nuclei
Diagnosis[edit | edit source]
The diagnosis of NIFTP is primarily based on histological examination of the thyroid tissue. It requires careful evaluation to distinguish it from other forms of thyroid carcinoma, particularly the encapsulated follicular variant of papillary thyroid carcinoma.
The criteria for diagnosing NIFTP include:
- Encapsulation or clear demarcation from surrounding tissue
- Follicular growth pattern
- Absence of true papillae
- No psammoma bodies
- No vascular or capsular invasion
Management[edit | edit source]
The management of NIFTP is less aggressive than that of other thyroid carcinomas due to its low risk of recurrence and excellent prognosis. Surgical removal of the affected lobe of the thyroid (lobectomy) is often sufficient, and total thyroidectomy is generally not required.
Prognosis[edit | edit source]
NIFTP has an excellent prognosis with a very low risk of recurrence or metastasis. The reclassification of this entity from a carcinoma to a neoplasm reflects its indolent nature and aims to prevent overtreatment.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
