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NUAK2[edit | edit source]
NUAK2, also known as NUAK family SNF1-like kinase 2, is a protein encoded by the NUAK2 gene in humans. This protein is a member of the AMP-activated protein kinase (AMPK) family, which plays a crucial role in cellular energy homeostasis. NUAK2 is involved in various cellular processes, including cell proliferation, apoptosis, and metabolism.
Structure[edit | edit source]
NUAK2 is a serine/threonine kinase that shares structural similarities with other members of the AMPK family. It contains a conserved kinase domain, which is responsible for its enzymatic activity. The protein also has regulatory domains that modulate its activity in response to cellular signals.
Function[edit | edit source]
NUAK2 is primarily involved in the regulation of cellular energy balance. It is activated in response to low energy conditions, such as nutrient deprivation or increased energy demand. Once activated, NUAK2 phosphorylates target proteins that are involved in metabolic pathways, thereby promoting energy conservation and adaptation to stress.
NUAK2 has also been implicated in the regulation of cell cycle progression and apoptosis. It can influence the expression of genes involved in these processes, thereby affecting cell survival and proliferation.
Clinical Significance[edit | edit source]
Alterations in NUAK2 expression or activity have been associated with various diseases, including cancer and metabolic disorders. Overexpression of NUAK2 has been observed in certain types of cancer, where it may contribute to tumor growth and survival. Conversely, reduced NUAK2 activity has been linked to metabolic dysfunctions, such as insulin resistance and obesity.
Research Directions[edit | edit source]
Ongoing research is focused on understanding the precise mechanisms by which NUAK2 regulates cellular processes and its potential as a therapeutic target. Studies are exploring the development of small molecule inhibitors or activators of NUAK2 as potential treatments for cancer and metabolic diseases.
Also see[edit | edit source]
- AMP-activated protein kinase
- Cellular metabolism
- Serine/threonine kinase
- Cancer metabolism
- Apoptosis
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Resources[edit source]
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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Noora for any updates.
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Contributors: Prab R. Tumpati, MD
