Norepinephrine-dopamine reuptake inhibitor

Norepinephrine-dopamine reuptake inhibitors (NDRIs) are a class of pharmacological agents that play a significant role in treating various mental disorders. They function by inhibiting the reuptake of the neurotransmitters norepinephrine and dopamine, thereby increasing the levels of these neurotransmitters in the brain.

Mechanism of Action

NDRIs work by blocking the transport proteins that remove norepinephrine and dopamine from the synaptic cleft between neurons. This action results in an increased concentration of these neurotransmitters in the synaptic cleft, which allows them to continue to exert their effects on the post-synaptic neuron.

Uses

NDRIs are primarily used in the treatment of depression, attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. They are also used off-label for a variety of conditions, including chronic fatigue syndrome, fibromyalgia, and neuropathic pain.

Examples

Some examples of NDRIs include bupropion (Wellbutrin), methylphenidate (Ritalin), and atomoxetine (Strattera). Each of these drugs has a slightly different mechanism of action and is used for different indications.

Side Effects

Common side effects of NDRIs can include insomnia, dry mouth, nausea, dizziness, and anxiety. In rare cases, they can cause more serious side effects such as seizures or psychosis.

See Also

• Selective serotonin reuptake inhibitors
• Serotonin-norepinephrine reuptake inhibitors
• Monoamine oxidase inhibitors