Norketamine
Norketamine is a metabolite of the anesthetic drug ketamine. It is formed in the body after administration of ketamine, and has similar effects to the parent drug. Norketamine is less potent than ketamine, but has a longer half-life.
Pharmacology[edit | edit source]
Norketamine acts as an NMDA receptor antagonist, which means it blocks the action of the neurotransmitter glutamate at NMDA receptors. This is thought to be the main mechanism by which it produces its anesthetic effects. Norketamine also has activity at other receptors, including the opioid receptors and the sigma receptors, which may contribute to its effects.
Metabolism[edit | edit source]
Norketamine is formed from ketamine in the body by the action of the enzyme CYP3A4. This is a major metabolic pathway for ketamine, and the amount of norketamine formed can vary depending on the activity of this enzyme in individual people.
Clinical significance[edit | edit source]
Norketamine is less potent than ketamine, but because it has a longer half-life, it can contribute to the effects of ketamine administration, particularly during prolonged infusions. It is also possible that norketamine could contribute to the side effects of ketamine, such as hallucinations and other psychotomimetic effects.
See also[edit | edit source]
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