Notch regulated ankyrin repeat protein
Notch Regulated Ankyrin Repeat Protein
The Notch Regulated Ankyrin Repeat Protein (NRARP) is a protein that plays a crucial role in the regulation of the Notch signaling pathway. It is characterized by the presence of ankyrin repeat domains, which are known for their involvement in protein-protein interactions.
Structure[edit | edit source]
NRARP consists of multiple ankyrin repeat domains that facilitate its binding to various target proteins involved in the Notch signaling cascade. These repeats are essential for the proper functioning of NRARP in modulating Notch signaling activity.
Function[edit | edit source]
NRARP acts as a negative regulator of the Notch signaling pathway by interacting with key components of the pathway and modulating their activity. By doing so, NRARP helps to fine-tune the Notch signaling response and ensure proper cellular processes such as cell differentiation and proliferation.
Regulation[edit | edit source]
The expression and activity of NRARP are tightly regulated to maintain the delicate balance of Notch signaling in cells. Various factors, including Notch receptors and ligands, can influence the levels and function of NRARP, thereby impacting the overall output of the Notch signaling pathway.
Clinical Relevance[edit | edit source]
Aberrant regulation of NRARP has been implicated in various diseases, including cancer and developmental disorders. Dysregulation of NRARP expression or function can disrupt Notch signaling dynamics, leading to pathological conditions.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
