Nuclear receptor co-repressor 2

Nuclear receptor co-repressor 2 (NCOR2), also known as silencing mediator for retinoid or thyroid-hormone receptors (SMRT), is a protein that in humans is encoded by the NCOR2 gene.

Function

NCOR2 is a transcriptional corepressor that mediates the transcriptional repression of nuclear receptors in the absence of ligand. It is involved in the regulation of gene expression by interacting with histone deacetylases (HDACs) and other components of the chromatin remodeling complex. This interaction is crucial for the repression of target genes by nuclear receptors such as the thyroid hormone receptor and the retinoic acid receptor.

Interactions

NCOR2 has been shown to interact with several proteins, including:

• Histone deacetylase 3 (HDAC3)
• Retinoic acid receptor alpha (RARA)
• Thyroid hormone receptor beta (THRB)
• Peroxisome proliferator-activated receptor gamma (PPARG)

These interactions are essential for the recruitment of NCOR2 to the promoter regions of target genes, where it exerts its repressive effects.

Clinical significance

Mutations or dysregulation of NCOR2 have been implicated in various diseases, including certain types of cancer and metabolic disorders. The role of NCOR2 in cancer is particularly significant, as it can influence the expression of genes involved in cell proliferation and apoptosis.

See also

• Nuclear receptor co-repressor 1 (NCOR1)
• Transcriptional coregulator
• Chromatin remodeling

External links

• Template:GeneReviews
• Online Mendelian Inheritance in Man (OMIM) 600849