Nucleoporin 214

Nucleoporin 214 (also known as Nup214 or CANE) is a protein that in humans is encoded by the NUP214 gene. It is a component of the nuclear pore complex, a structure that regulates the transport of molecules between the nucleus and the cytoplasm.

Structure

Nup214 is a large protein, with a molecular weight of approximately 214 kDa. It is composed of multiple domains, including a coiled coil region and a C-terminal domain that contains multiple zinc finger motifs. The protein is anchored to the nuclear pore complex via its N-terminal region.

Function

Nup214 plays a crucial role in the transport of proteins and RNA molecules between the nucleus and the cytoplasm. It is involved in the export of mRNA and proteins from the nucleus to the cytoplasm, and it also plays a role in the import of proteins into the nucleus. In addition, Nup214 is involved in the regulation of cell cycle progression and cell division.

Clinical significance

Mutations in the NUP214 gene have been associated with several types of cancer, including acute lymphoblastic leukemia and acute myeloid leukemia. In these cases, the NUP214 gene is often fused with other genes, leading to the production of a hybrid protein that promotes the growth of cancer cells.

File:Nup214 structure.png

Structure of the Nup214 protein. The coiled coil region is shown in red, and the zinc finger motifs are shown in blue.

See also

• Nuclear pore
• Nucleoporin
• Leukemia