Nucleoside-diphosphatase

Nucleoside-diphosphatase is an enzyme that catalyzes the hydrolysis of nucleoside diphosphates. This enzyme plays a crucial role in the metabolism of purines and pyrimidines, which are vital components of nucleic acids such as DNA and RNA.

Function

Nucleoside-diphosphatase is involved in the process of nucleotide degradation, where it catalyzes the conversion of nucleoside diphosphates into nucleoside monophosphates and inorganic phosphate. This reaction is important for the regulation of nucleotide pools within the cell, ensuring that there is a balance between the synthesis and degradation of nucleotides.

Structure

The structure of nucleoside-diphosphatase is highly conserved across different species, indicating its importance in cellular function. The enzyme is typically composed of a single polypeptide chain, with a catalytic site that binds to the nucleoside diphosphate substrate.

Clinical significance

Alterations in the activity of nucleoside-diphosphatase have been associated with several diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. In particular, increased activity of this enzyme has been observed in certain types of cancer, suggesting that it may play a role in tumor growth and progression.

See also

• Nucleoside
• Nucleotide
• Enzyme
• Purine metabolism
• Pyrimidine metabolism