OEA

Oleoylethanolamide (OEA) is a naturally occurring ethanolamide lipid that regulates feeding and body weight in animals and humans. It is synthesized in the small intestine and is believed to play a role in the sensation of satiety following a meal.

Synthesis and Mechanism of Action[edit | edit source]

OEA is synthesized in the small intestine from dietary fat, specifically oleic acid. It is produced in response to the presence of fat in the intestine and is released into the bloodstream, where it travels to the brain and other organs. OEA binds to a receptor called peroxisome proliferator-activated receptor alpha (PPAR-alpha), which is involved in the regulation of lipid metabolism and inflammation. Activation of PPAR-alpha by OEA leads to a decrease in food intake and an increase in energy expenditure, resulting in weight loss.

Role in Satiety and Weight Regulation[edit | edit source]

OEA has been shown to reduce food intake and increase energy expenditure in animal studies. It is believed to do this by enhancing the sensation of fullness or satiety following a meal. OEA also appears to have a role in regulating body weight, as administration of OEA to overweight animals results in weight loss.

Potential Therapeutic Applications[edit | edit source]

Due to its effects on food intake and body weight, OEA has potential therapeutic applications in the treatment of obesity and related metabolic disorders. However, more research is needed to fully understand the mechanisms of action of OEA and to determine its safety and efficacy in humans.

References[edit | edit source]

OEA Resources
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