OR2B11

OR2B11 is a gene that encodes a protein in the olfactory receptor family. The olfactory receptor family is the largest in the genome. The family members are G-protein coupled receptors that respond to odor molecules and are responsible for our sense of smell. The OR2B11 gene is specifically expressed in the olfactory epithelium.

Function

The OR2B11 gene encodes a member of the olfactory receptor family of proteins. These proteins are a part of the G protein-coupled receptor superfamily. The receptors in this family are responsible for detecting odor molecules in the nose and initiating a neuronal response that triggers the perception of a smell. The olfactory receptor gene family is the largest in the genome, and the specific function of this receptor has not been determined.

Expression

The OR2B11 gene is predominantly expressed in the olfactory epithelium, a specialized epithelial tissue inside the nasal cavity that is involved in smell. In humans, the olfactory epithelium is about 2.5 square centimeters, and is located in the upper part of the nasal cavity.

Clinical Significance

While the specific function of the OR2B11 gene is not yet fully understood, mutations in this gene and others in the olfactory receptor family have been associated with a decreased sense of smell, known as anosmia. Further research is needed to understand the potential clinical significance of this gene.

File:Olfactory system diagram en.svg

Diagram of the olfactory system, showing the olfactory epithelium (green).

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia