OR2D2

OR2D2 is a gene that encodes the olfactory receptor, family 2, subfamily D, member 2 protein in humans. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Function

The protein encoded by the OR2D2 gene is an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes.

Gene

The OR2D2 gene is located on the chromosome 1 (1q44). The gene spans approximately 1.1 kilobases and consists of 1 exon. The OR2D2 gene produces a mRNA molecule of approximately 1.1 kb in length.

Clinical Significance

While the specific clinical significance of OR2D2 is not yet fully understood, olfactory receptors in general are thought to have roles in various human diseases such as cancer, neurodegenerative diseases, and genetic disorders. Further research is needed to elucidate the potential roles of OR2D2 in human health and disease.

File:OR2D2 gene location on human chromosome 1.png

Location of OR2D2 gene on human chromosome 1.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Chromosome 1

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