OR4C12

OR4C12 is a gene that encodes a protein in the olfactory receptor family. This family is a group of G protein-coupled receptors which are responsible for detecting molecules in the environment and subsequently initiating a neuronal response. The olfactory receptor proteins interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.

Function

The olfactory receptor family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. The OR4C12 gene is a member of the olfactory receptor family, and like other members of this family, it is believed to function in the detection of odorants.

Structure

The OR4C12 gene is located on chromosome 11, specifically at 11p15.4. It spans approximately 1.1 kilobases and consists of a single exon. The OR4C12 protein is a member of the class A rhodopsin-like family of G protein-coupled receptors. It is composed of 312 amino acids and has a predicted molecular weight of approximately 35 kDa.

Clinical Significance

While the specific role of OR4C12 in human health and disease is not yet fully understood, olfactory receptors in general have been implicated in a variety of physiological and pathological processes. These include roles in immunity, reproduction, and disease detection. Further research is needed to elucidate the specific functions and potential clinical relevance of OR4C12.

File:OR4C12 gene location on human chromosome 11.png

Location of the OR4C12 gene on human chromosome 11.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Chromosome 11 (human)