OR4C12

OR4C12 is a gene that encodes a member of the olfactory receptor family of proteins. These receptors are part of the G protein-coupled receptor (GPCR) superfamily, which are responsible for detecting odor molecules and initiating the sense of smell.

Function

The OR4C12 gene is involved in the detection of odorant molecules in the olfactory system. Olfactory receptors, including OR4C12, are located in the olfactory epithelium of the nasal cavity. They interact with odorant molecules to initiate a neuronal response that is transmitted to the olfactory bulb in the brain, leading to the perception of smell.

Structure

Olfactory receptors like OR4C12 share a common structure with other GPCRs, characterized by seven transmembrane domains. This structure allows them to traverse the cell membrane and interact with G proteins inside the cell, which then trigger a cascade of intracellular events.

Genetic Information

The OR4C12 gene is located on chromosome 11 at the q11.2 band. It is part of a large family of olfactory receptor genes that are distributed throughout the human genome. These genes are highly diverse, allowing humans to detect a wide range of odors.

Clinical Significance

While the primary function of OR4C12 is related to olfaction, variations in olfactory receptor genes can influence individual differences in smell perception. However, specific clinical conditions directly associated with OR4C12 have not been extensively documented.

See Also

• Olfactory receptor family
• G protein-coupled receptor
• Olfactory system

External Links

• OR4C12 Gene - NCBI
• OR4C12 Gene - GeneCards