OR51E2

OR51E2 also known as Olfactory Receptor Family 51 Subfamily E Member 2 is a protein that in humans is encoded by the OR51E2 gene. It is a member of the olfactory receptor family of genes, which are the largest gene family in the genome.

Function

The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Clinical significance

OR51E2 is also known as a prostate-specific G-protein coupled receptor (PSGR), and has been found to be upregulated in prostate cancer. It has been suggested that OR51E2 may be a useful target for the treatment of prostate cancer.

See also

• Olfactory receptor
• G protein-coupled receptor
• Prostate cancer

External links

• GeneCards: OR51E2

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