Oclacitinib
An article about the medication Oclacitinib
Oclacitinib | |
---|---|
![]() | |
INN | |
Drug class | |
Routes of administration | |
Pregnancy category | |
Bioavailability | |
Metabolism | |
Elimination half-life | |
Excretion | |
Legal status | |
CAS Number | |
PubChem | |
DrugBank | |
ChemSpider | |
KEGG |
Oclacitinib is a medication used in veterinary medicine primarily for the treatment of allergic dermatitis and pruritus in dogs. It is a selective Janus kinase (JAK) inhibitor, which helps to reduce inflammation and itchiness by interfering with the signaling pathways that lead to these symptoms.
Mechanism of Action[edit | edit source]
Oclacitinib works by inhibiting the activity of Janus kinase enzymes, specifically JAK1 and JAK3. These enzymes are involved in the signaling pathways of various cytokines that play a role in the inflammatory and pruritic processes. By blocking these pathways, oclacitinib reduces the production of inflammatory mediators and alleviates symptoms associated with allergic reactions.
Uses[edit | edit source]
Oclacitinib is primarily used to manage allergic dermatitis and pruritus in dogs. It is effective in reducing itching and inflammation associated with various allergic conditions, including atopic dermatitis.
Administration[edit | edit source]
Oclacitinib is administered orally, and the dosage is typically based on the weight of the dog. It is important to follow the veterinarian's prescription to ensure the effectiveness and safety of the treatment.
Side Effects[edit | edit source]
Common side effects of oclacitinib may include vomiting, diarrhea, and anorexia. In some cases, dogs may experience more serious side effects such as immunosuppression, which can increase the risk of infections.
Precautions[edit | edit source]
Oclacitinib should be used with caution in dogs with a history of neoplasia or immunosuppression. It is not recommended for use in dogs less than 12 months of age or in breeding, pregnant, or lactating dogs.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD