Ohmefentanyl

Ohmefentanyl

Ohmefentanyl is a potent synthetic opioid that is derived from fentanyl. It is most commonly used in the field of pharmacology for research purposes. Ohmefentanyl is one of the most potent μ-opioid receptor agonists currently known, up to 100 times more potent than fentanyl. This makes it a highly potent analgesic, although it is not currently used in human medicine.

Chemistry

Ohmefentanyl is part of the 4-anilidopiperidine class of opioids. It is closely related to other fentanyl derivatives such as alfentanil, sufentanil, and carfentanil, but is distinguished by its particular chemical structure. The molecule consists of a piperidine ring, to which an N-phenylpropionamido group is attached. The stereochemistry of the molecule is important for its activity, with the most active isomer being the one where the aromatic ring is in the cis position relative to the carboxy group.

Pharmacology

Ohmefentanyl acts primarily on the μ-opioid receptor, where it has extremely high affinity. This receptor is responsible for the analgesic effects of opioids, as well as many of their side effects. The potency of ohmefentanyl is due to its high lipophilicity, which allows it to cross the blood-brain barrier and reach the central nervous system rapidly.

Effects

The effects of ohmefentanyl are similar to those of other opioids. These include strong analgesia, sedation, euphoria, and respiratory depression. However, due to its extreme potency, the risk of overdose and respiratory depression is high. It is therefore not used clinically, but is instead used in research to study the μ-opioid receptor and the effects of highly potent opioids.

Legal status

Ohmefentanyl is a controlled substance in many countries, including the United States, where it is classified as a Schedule I drug under the Controlled Substances Act. This means that it has a high potential for abuse and no accepted medical use.

See also

• Fentanyl
• Opioid
• μ-opioid receptor