Oltipraz
Oltipraz is a dithiolethione derivative that has been studied for its potential use in cancer prevention and chemoprotection. It was originally developed as an antiparasitic agent, but its role in inducing Phase II enzymes led to its investigation as a chemoprotective agent.
History[edit | edit source]
Oltipraz was first synthesized in the 1970s as a potential treatment for schistosomiasis, a parasitic disease. However, its ability to induce Phase II enzymes, which are involved in the detoxification of carcinogens, led to its investigation for cancer prevention.
Mechanism of Action[edit | edit source]
Oltipraz exerts its chemoprotective effects by inducing Phase II enzymes, including glutathione S-transferases (GSTs) and quinone reductase (QR). These enzymes are involved in the detoxification of carcinogens and reactive oxygen species, thereby reducing the risk of DNA damage and cancer development. Oltipraz is thought to induce these enzymes through the Keap1-Nrf2-ARE pathway, a major regulatory pathway for Phase II enzymes.
Clinical Trials[edit | edit source]
Several clinical trials have been conducted to evaluate the potential of Oltipraz in cancer prevention. These trials have focused on various types of cancer, including lung cancer, liver cancer, and colorectal cancer. While some trials have shown promising results, others have not found a significant benefit of Oltipraz in reducing cancer risk.
Side Effects[edit | edit source]
The most common side effects of Oltipraz include nausea, vomiting, and diarrhea. In some cases, Oltipraz may also cause rash, headache, and dizziness.
Current Status[edit | edit source]
As of now, Oltipraz is not approved for use in cancer prevention by the Food and Drug Administration (FDA) or any other regulatory authority. However, research on its potential benefits continues.
| IUPAC Name: | {{{IUPACName}}} |
| Other Names: | |
| Identifiers | |
| CAS Number | |
| PubChem | |
| ChemSpider | |
| SMILES | |
| InChI | |
| InChIKey | |
| StdInChI | |
| StdInChIKey | |
| Properties | |
| Chemical formula | CHNO |
| Appearance | |
| Density | |
| Melting Point | |
| Boiling Point | |
| Solubility | |
| Hazards | |
| Main Hazards | |
| Flash Point | |
| Autoignition Temperature | |
| Drug Information | |||
|---|---|---|---|
| Image | |||
| Identifiers
CAS Number ATC Code PubChem DrugBank ChemSpider ID UNII KEGG ChEBI ChEMBL IUPAC Name |
Chemical Data
C H N O Molecular Weight | ||
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
