Orthotopic

Orthotopic is a term used in medicine and biology to describe the natural or normal place of an organ or tissue. It is often used in the context of transplantation or grafting, where an organ or tissue is placed in its normal position in the body. The opposite of orthotopic is heterotopic, which refers to an organ or tissue being placed in an unnatural or abnormal position.

Orthotopic Transplantation

Orthotopic transplantation is a surgical procedure where an organ or tissue is removed from one individual and placed in the same location in another individual. This is the most common type of transplantation, and it includes procedures such as heart transplantation, liver transplantation, and kidney transplantation.

Orthotopic Tumor Models

In oncology, orthotopic models are used to study the growth of tumors in their natural environment. These models are considered more clinically relevant than ectopic models, where tumors are grown in unnatural locations.

Orthotopic Heart Transplantation

In orthotopic heart transplantation, the donor's heart is placed in the recipient's chest, replacing their own heart. This is the most common method of heart transplantation.

Orthotopic Liver Transplantation

Orthotopic liver transplantation involves the replacement of a diseased liver with a healthy one from a donor. The new liver is placed in the same anatomical position as the original liver.

See Also

• Transplantation
• Grafting
• Heterotopic
• Ectopic

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